|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Methylenetetrahydrofolate reductase gene (MTHFR), transcobalaminII (TCN2) and ring finger protein 213 (RNF213) are related to homocysteine (Hcy) level and are of great significance for hypertension.
|
31815282 |
2019 |
|
Spinocerebellar Ataxia Type 2
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
MTHFR A1298C polymorphism is associated with saccade latency in SCA2 patients, but not with disease risk, age at onset or maximal saccade velocity.
|
31812845 |
2020 |
|
Motor neuron atrophy
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
In particular, we assessed the impact of MTHFR as rate-limiting enzyme in DNA methylation pathways, which modulates cerebellar neurotransmission and motor neuron atrophy.
|
31812845 |
2020 |
|
Childhood Acute Lymphoblastic Leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To analyze influence of variants in TYMS, MTHFR, SLC19A1 and DHFR genes on 6-mercaptopurine (MP) induced toxicity during maintenance phase of treatment for childhood acute lymphocytic leukemia (ALL).
|
31786878 |
2020 |
|
Vitiligo
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Determine serum homocysteine levels in vitiligo patients as well as the association between MTHFR (C677T, A1298C) and CBSgene polymorphisms and susceptibility to vitiligo in a sample of those populations.
|
31778995 |
2020 |
|
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Determine serum homocysteine levels in vitiligo patients as well as the association between MTHFR (C677T, A1298C) and CBSgene polymorphisms and susceptibility to vitiligo in a sample of those populations.
|
31778995 |
2020 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Further subgroup analyses in the Chinese population indicated that MTHFR C677T variant was associated with a higher risk of ischemic stroke.
|
31775641 |
2019 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The MTHFR C677T genotype and serum vitamin B<sub>2</sub> or B<sub>12</sub> levels may interact in ways which associated with the EPL and ESCC risks.
|
31754346 |
2019 |
|
cervical cancer
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
PCR-DNA analysis was used to explore the genotype of the SNPs (rs4846048 and rs55763075) of the MTHFR 3'-UTR as well as the association between allelic frequencies and the CC risk.
|
31750632 |
2020 |
|
Malignant tumor of cervix
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
PCR-DNA analysis was used to explore the genotype of the SNPs (rs4846048 and rs55763075) of the MTHFR 3'-UTR as well as the association between allelic frequencies and the CC risk.
|
31750632 |
2020 |
|
Cervix carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
PCR-DNA analysis was used to explore the genotype of the SNPs (rs4846048 and rs55763075) of the MTHFR 3'-UTR as well as the association between allelic frequencies and the CC risk.
|
31750632 |
2020 |
|
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Low red blood cell folate combined with MTHFR 677C > T polymorphism statistically increased CRC risk (OR = 10.00, 95% CI = 1.36-73.42).
|
31740010 |
2019 |
|
Adenoma of large intestine
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This case-control study enrolled 105 new cases of CRC, 101 of colorectal adenoma (CRA), and 182 controls from hospitals in Bangkok, Thailand, to examine the association between folate status and methylenetetrahydrofolate reductase (MTHFR) 677C > T, methionine synthase (MTR) 2756A > G, and methionine synthase reductase (MTRR) 66A > G with the risk of CRC and CRA.
|
31740010 |
2019 |
|
Malignant neoplasm of colon and/or rectum
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Low folate status, and MTHFR 677C > T and MTR 2756A > G polymorphisms associated with colorectal cancer risk in Thais: a case-control study.
|
31740010 |
2019 |
|
Migraine Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, the variability of the methylenetetrahydrofolate reductase gene, important in both folate metabolism and migraine pathogenesis, modulates the beneficial effects of folate for migraines.
|
31739474 |
2019 |
|
Childhood Acute Lymphoblastic Leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study was to investigate new genetic biomarkers for ALL by analyzing the MTHFR polymorphisms at the 3'-untranslated region, which is a location bound by miRNAs.
|
31737664 |
2019 |
|
Seizures
|
0.440 |
GeneticVariation
|
phenotype |
BEFREE |
Children with MTHFR C677T or A1298C polymorphisms who had normal neurological examination without a history of seizure were included in the study.
|
31734877 |
2020 |
|
Thrombophilia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The laboratory tests revealed high D-dimers, and positive IgG anti-cardiolipin and anti-beta2 glycoproteins I antibodies, whereas the genetic profile for thrombophilia revealed heterozygote mutation in MTHFR C677T and A1298C genes.
|
31725629 |
2019 |
|
Pancreatic carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Thus, we conducted a meta-analysis to summarize available data on MTHFR gene and PC.
|
31701291 |
2020 |
|
Malignant neoplasm of pancreas
|
0.090 |
Biomarker
|
disease |
BEFREE |
Thus, we conducted a meta-analysis to summarize available data on MTHFR gene and PC.
|
31701291 |
2020 |
|
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In summary, our findings suggested that MTHFR rs3753584, rs9651118 and rs1801133 polymorphisms may affect the risk of HCC in Chinese Han population.
|
31694048 |
2019 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
One hundred ninety-six children with obesity (101 females, 95 males) were evaluated using anthropometric measurements, dietary intakes, plasma and RBC PUFA quantification, blood biochemistry, and 55 single nucleotide polymorphisms within 14 genes. phosphatidylethanolamine <i>N</i>-methyltransferase (<i>PEMT</i>) rs1109859 and methylenetetrahydrofolate reductase gene (<i>MTHFR</i>) rs4846052 genotypes were associated with PUFA levels in RBCs.
|
31671528 |
2019 |
|
Oral cleft
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In the present investigation a set of 34 triads with oral cleft from Nassiriya, Iraq, has been genotyped for rs1801133 of MTHFR, rs1801198 of TCN2, and rs4920037 of CBS polymorphisms.
|
31663440 |
2020 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Methylenetetrahydrofolate reductase (MTHFR) is essential in mediating folate metabolism, and thus plays an important role in diabetes and diabetic complications.
|
31663297 |
2019 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Methylenetetrahydrofolate reductase (MTHFR) is essential in mediating folate metabolism, and thus plays an important role in diabetes and diabetic complications.
|
31663297 |
2019 |